Segmental Vitiligo Natural History And Prognosis
Breakthrough segmental vitiligo cure Disvovered by Michael DawsonThere is limited data concerning the natural history and prognosis of vitiligo. A prognostic study should be based on a representative sample of affected individuals followed for a sufficiently long period of time, loss to follow-up should be reduced to a minimum, outcome measures should be clearly defined at the beginning of the study, and adequate analytical methods should employed (survival analysis, Cox models).
Pathological Conditions Associated with Vitiligo
IgA selective defect
Thyroid diseases (frequently associated with autoantibodies)
Congenital melanocytic nevi
MELAS syndrome (mitochondrial encephalomyopathy,
lactic acidosis, and stroke episodes syndrome)
Segmental Vitiligo Cure
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Segmental vitiligo, which in many series accounts for 10-20% of the affected individuals, have an earlier onset and a more rapid evolution as compared with generalized vitiligo
Moreover, segmental vitiligo is rarely associated with immune-related disorders, the Koebner phenomenon, or stressful life events. Once it appears, vitiligo follows a chronic course. In segmental vitiligo, disease activity seems usually to cease with the extension of the disease to the involved dermatome within one year, while new lesions can appear lifelong in generalized vitiligo. In a cohort study involving 61 patients, the Koebner phenomenon, experimentally induced, had a prognostic value
correlated with disease activity.
Breakthrough Segmental Vitiligo Cure DiscoveredAccording to a survey conducted on a large sample of patients members of the U.K. Vitiligo Society, only about 14% of patients experienced a spontaneous improvement of their disease at some point during their life. Patients with a more limited extension of the disease more frequently reported spontaneous improvement compared to patients with more extensive disease. Vitiligo has a remarkable impact on the patient’s quality of life, wellbeing,and social life. It has been documented that an intervention providing psychological support according to a cognitive-behavioral paradigm may have an impact on the disease burden and severity.
Little data is available concerning factors that may influence therapeutic choices and preferencesof patients and physicians. In the already mentioned survey involving members of the U.K. Vitiligo Society, about 40% of male patients and 70% offemales reported a regular use of camouflage, while only about 20% of allpatients had undertaken a medical or surgical procedures at the same stage of their vitiligo disease. A survey of 332 Dutch dermatologists documented that only 16% of all dermatologists regularly offered their vitiligo patients an active vitiligo treatment. There was no consensus on the active treatment of choice. Such a situation may be common to other countries. In Holland it has been documented that the development and dissemination of clinical guidelines based on the results of three systematic reviews resulted in better agreement between dermatologists on treatment strategies. These systematic reviews indicated that topical high-potency steroids and narrow-band ultraviolet B light irradiation were the treatment modalities supported by the best available evidence for, respectively, localized vitiligo and generalized vitiligo.
Vitiligo is a relatively common skin disease affecting 3-5 individuals per 1000 people. The causative model probably involves genetic-environmental interaction, but the environmental factors are largely unknown. Epidemiological research may contribute to a better understanding of the etiological and prognostic factors and aid in the evaluation of the long-term outcome of the disease, improving its management.
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